Scientific Name: Macaca fascicularis
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Primates-> Haplorrhini-> Simiiformes-> Catarrhini-> Cercopithecoidea-> Cercopithecidae-> Cercopithecinae
Summary: This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008] [NCBI] [Proteinatlas]
Data set information
Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
---|---|---|---|---|---|---|
Vthunter_1027 | 2019.11 | 10X Genomics | AorticArtery | Normal | 4383 | Link |
Vthunter_1028 | 2019.11 | 10X Genomics | CoronaryArtery | Normal | 3606 | Link |
Vthunter_110069 | 2019.12 | MARS-seq | TotalBrain | Normal | 768 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues